By the end of my research study on Wnts, I had learnt the name of the game was “troubleshooting and perseverance”. The Wnts are challenging proteins to express and purify due to their basic structure, amino acid composition and post translational modifications. However, my consistent nano-progress landed me an opportunity to share my research findings …

  At the start of my doctoral training, I wanted to conduct a research study in cancer therapeutics. When I came across nutlin-3a, an anti-MDM2 small molecule developed by Roche with poor aqueous solubility, I jumped at the opportunity to work with the compound to improve its bioavailability. Since apolipoproteins and phospholipids are naturally found …

Doctora The heart and soul of my doctoral thesis was related to the “Wnt” protein.Wnt signaling controls a variety of adult and developmental processes. The need to prevent the inappropriate activation of Wnt signaling is underscored by the fact that mis-regulation of Wnt signal transduction pathway leads to tumor formation. Thus, understanding the mechanisms that …