Krishnamoorthy A, Tavoosi N, Chan GK, Liu J, Ren G, Cavigiolio G and Ryan RO. “Effect of curcumin on amyloid-like aggregates generated from methionine oxidized apolipoprotein A-I.” FEBS Open Bio, 8 (2), 302-310. Krishnamoorthy A, Witkowski A, Ryan RO. “Nutlin-3a nanodisks induce p53 stabilization and apoptosis in a subset of cultured glioblastoma cells.” Journal …
By the end of my research study on Wnts, I had learnt the name of the game was “troubleshooting and perseverance”. The Wnts are challenging proteins to express and purify due to their basic structure, amino acid composition and post translational modifications. However, my consistent nano-progress landed me an opportunity to share my research findings …
At the start of my doctoral training, I wanted to conduct a research study in cancer therapeutics. When I came across nutlin-3a, an anti-MDM2 small molecule developed by Roche with poor aqueous solubility, I jumped at the opportunity to work with the compound to improve its bioavailability. Since apolipoproteins and phospholipids are naturally found …
Doctora The heart and soul of my doctoral thesis was related to the “Wnt” protein.Wnt signaling controls a variety of adult and developmental processes. The need to prevent the inappropriate activation of Wnt signaling is underscored by the fact that mis-regulation of Wnt signal transduction pathway leads to tumor formation. Thus, understanding the mechanisms that …
Under certain circumstances the process of kidney repair can be impeded, which can eventually lead to chronic kidney disease. Some of the most frequently reported risk factors for non-recovery following kidney injury include age, severity of disease, hypertension, diabetes mellitus and cardiac disease. Based on my research expertise in kidney injury and identification of the role …
I identified for the first time that fibrinogen, a protein typically expressed in the liver and found in the blood, is in fact expressed and significantly regulated in the kidney after acute kidney injury. I also demonstrated the novel therapeutic potential of a fibrinogen-derived peptide that protects the kidney from kidney injury by increasing kidney …
Recurrent episodes of acute kidney injury are a major concern in the medical field, and follow-up programs aim prevention and early detection of acute kidney injury, including early assessment and advice regarding the avoidance of nephrotoxin exposure. Addressing this extremely pressing issue in human health and disease management, I published novel findings in the journal …
The findings of my Master’s thesis highlighted the process of spontaneous differentiation of human embryonic stem cells and identified factors that can vastly influence the differentiation status of the cells. In addition, my novel approach of picking and reseeding single cells for colony formation and analyzing the cells, established a way to maintain the intactness of …
Abstract Human embryonic stem (hES) cells are capable of differentiating into a wide range of specialized cell types. Analysis of hES cells at the single colony or single cell level under cultured conditions is critical to understanding the molecular basis of hES cell differentiation. We have developed a new approach, in which single colonies of …
The city of Coimbatore in India has many textile manufacturing and dyeing industries that need to pretreat the industry generated effluent before releasing it into the environment. As a part of my undergraduate thesis, I researched on microbial consortia and enzyme extractions from microbes that can be used as part of pretreatment conditions for environmental …